Individualization of the Immunosuppressive Therapy in Patients of Renal Transplantations through Pharmacodynamic and Pharmacogenetic Biomarkers

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Dokumentart: PhDThesis
Date: 2017
Language: English
Faculty: 4 Medizinische Fakultät
Department: Medizin
Advisor: Wieland, Eberhard (Prof. Dr.)
Day of Oral Examination: 2017-02-10
DDC Classifikation: 610 - Medicine and health
Keywords: Pharmakologie , Transplantation
Other Keywords:
Immunosuppressive drugs
organ transplantation
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The aim of this work was to look for specific biomarkers that could help to guide therapy with immunosuppressive drugs after organ transplantation. This work entailed the analytical validation of two pharmacodynamic biomarker assays. These include “NFAT-regulated gene expression assay” to monitor therapy with calcineurin inhibitors and “phosphoflow assay of S6RP” to monitor therapy with mTOR inhibitors. Additionally, a retrospective pharmacogenetic study to investigate the frequency and the impact of 6 SNPs in the genes of CYP450 and ABAB1 on tacrolimus pharmacokinetics early after transplantation in a cohort of 121 renal transplant recipients was also conducted.

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