Design, Synthesis, and Molecular Evaluation of SNAr-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode

Ernst, Larissa N.; Stahlecker, Jason; Mier, Finn; Serafim, Ricardo A. M.; Wydra, Valentin R.; Masberg, Benedikt; Jaag, Simon J.; Knappe, Cornelius; Lammerhofer, Michael; Stehle, Thilo; Gehringer, Matthias; Boeckler, Frank M.

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dc.contributor.author	Ernst, Larissa N.
dc.contributor.author	Stahlecker, Jason
dc.contributor.author	Mier, Finn
dc.contributor.author	Serafim, Ricardo A. M.
dc.contributor.author	Wydra, Valentin R.
dc.contributor.author	Masberg, Benedikt
dc.contributor.author	Knappe, Cornelius
dc.contributor.author	Stehle, Thilo
dc.contributor.author	Gehringer, Matthias
dc.contributor.author	Boeckler, Frank M.
dc.contributor.author	Jaag, Simon
dc.contributor.author	Lämmerhofer, Michael
dc.date.accessioned	2026-06-02T08:36:57Z
dc.date.available	2026-06-02T08:36:57Z
dc.date.issued	2025
dc.identifier.issn	0365-6233
dc.identifier.uri	http://hdl.handle.net/10900/180179
dc.language.iso	en	de_DE
dc.publisher	Weinheim : Wiley - V C H Verlag Gmbh	de_DE
dc.relation.uri	http://dx.doi.org/10.1002/ardp.70053	de_DE
dc.subject.ddc	540	de_DE
dc.subject.ddc	610	de_DE
dc.title	Design, Synthesis, and Molecular Evaluation of SNAr-Reactive N-(6-Fluoro-3-Nitropyridin-2-yl)Isoquinolin-3-Amines as Covalent USP7 Inhibitors Reveals an Unconventional Binding Mode	de_DE
dc.type	Article	de_DE
utue.quellen.id	20251118000000_01214
utue.personen.roh	Ernst, Larissa N.
utue.personen.roh	Stahlecker, Jason
utue.personen.roh	Mier, Finn
utue.personen.roh	Serafim, Ricardo A. M.
utue.personen.roh	Wydra, Valentin R.
utue.personen.roh	Masberg, Benedikt
utue.personen.roh	Jaag, Simon J.
utue.personen.roh	Knappe, Cornelius
utue.personen.roh	Lammerhofer, Michael
utue.personen.roh	Stehle, Thilo
utue.personen.roh	Gehringer, Matthias
utue.personen.roh	Boeckler, Frank M.
dcterms.isPartOf.ZSTitelID	Archiv der Pharmazie	de_DE
dcterms.isPartOf.ZS-Issue	Article e70053	de_DE
dcterms.isPartOf.ZS-Volume	358 (8)	de_DE
utue.fakultaet	04 Medizinische Fakultät	de_DE
utue.fakultaet	07 Mathematisch-Naturwissenschaftliche Fakultät	de_DE