Design, Synthesis, and Biological Evaluation of Novel Type l1/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine

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Design, Synthesis, and Biological Evaluation of Novel Type l1/2 p38 alpha MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine

Author: Walter, Niklas M.; Wentsch, Heike K.; Buehrmann, Mike; Bauer, Silke M.; Doering, Eva; Mayer-Wrangowski, Svenja; Sievers-Engler, Adrian; Willemsen-Seegers, Nicole; Zaman, Guido; Buijsman, Rogier; Laemmerhofer, Michael; Rauh, Daniel; Laufer, Stefan A.
Tübinger Autor(en):
Walter, Niklas M.
Wentsch-Teltschik, Heike Kristin
Sievers-Engler, Adrian
Bauer, Silke Mona
Döring, Eva
Lämmerhofer, Michael
Laufer, Stefan
Published in: Journal of Medicinal Chemistry (2017), Bd. 60, H. 19, S. 8027-8054
Verlagsangabe: Amer Chemical Soc
Language: English
Full text: http://dx.doi.org/10.1021/acs.jmedchem.7b00745
ISSN: 1520-4804
DDC Classifikation: 540 - Chemistry and allied sciences
Dokumentart: Article
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