An algorithm to build a multi-genome reference and its application

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An algorithm to build a multi-genome reference and its application

Rabbani, Seyedeh Leily
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URI: http://hdl.handle.net/10900/85364
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-853645
http://dx.doi.org/10.15496/publikation-26754
http://nbn-resolving.org/urn:nbn:de:bsz:21-dspace-853643
http://nbn-resolving.org/urn:nbn:de:bsz:21-dspace-853643
Dokumentart: PhDThesis
Date: 2018-12-17
Language: English
Faculty: 7 Mathematisch-Naturwissenschaftliche Fakultät
Department: Biologie
Advisor: Weigel, Detlef (Prof. Dr.)
Day of Oral Examination: 2018-10-04
DDC Classifikation: 004 - Data processing and computer science
Keywords: Bioinformatik
Other Keywords:
Bioinformatics
reference genome
graph theory
License: http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en
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Abstract:

In this dissertation a method is proposed that allows a comparison against several high-quality reference genomes simultaneously. To this end, an algorithm has been developed that creates a graph as a multi-genome reference to remove the reference bias and to simplify downstream analysis.

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