Identification and characterization of a novel PAMP from a widespread microbial virulence factor and its perception system in Arabidopsis

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dc.contributor.advisor Nürnberger, Thorsten (Prof. Dr.)
dc.contributor.author Böhm, Hannah Undine
dc.date.accessioned 2016-03-21T06:15:25Z
dc.date.available 2016-03-21T06:15:25Z
dc.date.issued 2016
dc.identifier.other 462631273 de_DE
dc.identifier.uri http://hdl.handle.net/10900/68884
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-688847 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-10301
dc.description.abstract NEP1-like proteins (NLPs) are phytotoxins and microbial virulence factors secreted by bacteria, oomycetes and fungi capable of exerting immune responses in dicot plant species. Previously, this immunogenic activity has been linked to cytotoxicity, supposedly through toxin-mediated release of endogenous signals of danger called DAMPs (damage-associated molecular patterns). Here, immunogenic activity could be traced back to a 20 amino acid stretch within a Phytophthora parasitica-derived NLP, designated as nlp20. Immunogenic orthologous sequences can be found in NLPs of bacteria, oomycetes and fungi; a unique distribution pattern of all known PAMPs to date. Nlp20 is perceived by the Arabidopsis LRR-RP (leucine-rich repeat receptor protein) RLP23, likely forming a tripartite receptor complex with the LRR-RK-type (leucine-rich repeat receptor kinase) co-receptors SERK3/BAK1 (somatic embryogenesis receptor 3/BRI1-associated kinase 1) and SOBIR1/EVR (suppressor of BIR1-1/evershed) to facilitate downstream signaling. SOBIR1/EVR interacts constitutively and independent of nlp20 with RLP23, whereas SERK3/BAK1 gets recruited into the receptor complex in a nlp20-dependent fashion only. Interfamily transfer of RLP23 into the crop potato confers disease resistance against devastating pathogens such as Phytophthora infestans and Sclerotinia sclerotiorum, turning RLP23 into a promising candidate for future engineering of durable broad-spectrum disease resistance in important crops. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podno de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_ohne_pod.php?la=en en
dc.subject.classification Schmalwand <Arabidopsis> , Immunsystem , Rezeptor , Ligand , Virulenzfaktor , Pathogenität , Resistenz de_DE
dc.subject.ddc 500 de_DE
dc.subject.ddc 570 de_DE
dc.subject.ddc 580 de_DE
dc.title Identification and characterization of a novel PAMP from a widespread microbial virulence factor and its perception system in Arabidopsis en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2016-02-29
utue.publikation.fachbereich Biochemie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE

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