Investigation of lectin complement proteins in urinary schistosomiasis and visceral leishmaniasis

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dc.contributor.advisor Kremsner, Peter (Prof. Dr.) Selvaraj, Justin Antony 2016-02-23T09:54:46Z 2016-02-23T09:54:46Z 2016-02
dc.identifier.other 456141669 de_DE
dc.identifier.uri de_DE
dc.description.abstract Complement lectins are pathogen recognition receptors (PRRs) that bind to pathogen associated molecular patterns (PAMPs) of various microbes. The circulating serum levels and functional genetic variants of four such innate immune recognition elements, namely the human mannose-binding lectin (MBL), ficolin-2 (FCN2), collectin 11 (CL-K1), mannose-binding associated serine protease-2 (MASP2) were studied in intracellular (visceral leishmaniasis) and extracellular (urinary schistosomiasis) parasitic diseases. In extracellular Schistosoma haematobium infection, MBL, MASP2, and collectin-11 (CL- K1) and their functional variants were associated with relative protection. In intra-cellular Leishmania donovani infection, MBL, ficolin-2 and their functional variants were observed to be a susceptible host factor. IL-6 was observed to regulate the lectin expression during distinct parasitic infections. In conclusion, this dissertation provides probable evidence on the differential role of lectins in intra and extracellular infections. en
dc.description.abstract Komplement-Lektine sind sogenannte “pathogen recognition receptors” (PRRs), welche Pathogen-assoziierte molekulare Muster (“pathogen associated molecular patterns”, PAMPs) diverser Krankheitserreger erkennen. Ich untersuchte zirkulierenden Serumlevel und funktionelle genetische Varianten von vier solcher PRRs in einer intrazellulären (viszerale Leishmaniose) und einer extrazellulären (urogenitale Schistosomiase) Krankheit: Mannose-bindendes Lektin (MBL), Ficolin 2 (FCN2), Collektin 11 (CL-K1), und MBL assoziierte Serinprotease 2 (MASP2). In der extrazellulären Schistosoma haematobium Infektion waren MBL, MASP2, und Collektin 11, sowie deren funktionelle Varianten mit einem relativen Schutz gegen die Krankheit assoziiert. In der intrazellulären Leishmania donovani Infektion waren MBL, Ficolin 2, und deren funktionelle Varianten Suszeptibilitätsfaktoren. Während distinkter parasitischer Infektionen regulierte IL-6 die Lektinexpression. Zusammenfassend erbringt diese Dissertation diverse Beweise für die differentielle Rolle von Lektinen in intra- und extrazellulären parasitischen Infektionen. de_DE
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri de_DE
dc.rights.uri en
dc.subject.classification Parasitologie de_DE
dc.subject.ddc 570 de_DE
dc.subject.other Lectins en
dc.subject.other Schistosomiasis en
dc.subject.other visceral leishmaniasis en
dc.title Investigation of lectin complement proteins in urinary schistosomiasis and visceral leishmaniasis en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2016-01-21
utue.publikation.fachbereich Biologie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE


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