Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity

Flury, Philipp; Kruger, Nadine; Sylvester, Katharina; Breidenbach, Julian; Al Hamwi, Ghazl; Qiao, Jingxin; Chen, Yan; Rocha, Cheila; Serafim, Mateus Sa Magalhaes; Barbosa da Silva, Elany; Poehlmann, Stefan; Poso, Antti; Kronenberger, Thales; Rox, Katharina; O'Donoghue, Anthony J.; Yang, Shengyong; Strater, Norbert; Gutschow, Michael; Laufer, Stefan A.; Muller, Christa E.; Pillaiyar, Thanigaimalai

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Design, Synthesis, and Unprecedented Interactions of Covalent Dipeptide-Based Inhibitors of SARS-CoV-2 Main Protease and Its Variants Displaying Potent Antiviral Activity

Autor(en):

Flury, Philipp; Kruger, Nadine; Sylvester, Katharina; Breidenbach, Julian; Al Hamwi, Ghazl; Qiao, Jingxin; Chen, Yan; Rocha, Cheila; Serafim, Mateus Sa Magalhaes; Barbosa da Silva, Elany; Poehlmann, Stefan; Poso, Antti; Kronenberger, Thales; Rox, Katharina; O'Donoghue, Anthony J.; Yang, Shengyong; Strater, Norbert; Gutschow, Michael; Laufer, Stefan A.; Muller, Christa E.; Pillaiyar, Thanigaimalai

Tübinger Autor(en):

Flury, Philipp
Poso, Antti
Kronenberger, Thales
Laufer, Stefan
Pillaiyar, Thanigaimalai

Erschienen in:

Journal of Medicinal Chemistry (2025), Bd. 68, H. 3, S. 3626-3652

Verlagsangabe:

Washington : Amer Chemical Soc

Sprache:

Englisch

Referenz zum Volltext:

http://dx.doi.org/10.1021/acs.jmedchem.4c02254

ISSN:

0022-2623