Physiological Parameters Relevant to Dissolution Testing - Hydrodynamic Considerations (rev. and suppl. version)

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Zitierfähiger Link (URI): http://hdl.handle.net/10900/147222
http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1472228
http://dx.doi.org/10.15496/publikation-88563
Dokumentart: Teil eines Buches
Erscheinungsdatum: 2005
Sprache: Englisch
Fakultät: 7 Mathematisch-Naturwissenschaftliche Fakultät
Fachbereich: Pharmazie
DDC-Klassifikation: 500 - Naturwissenschaften
530 - Physik
540 - Chemie
570 - Biowissenschaften, Biologie
590 - Tiere (Zoologie)
610 - Medizin, Gesundheit
630 - Landwirtschaft, Veterinärmedizin
Freie Schlagwörter:
in vivo hydrodynamics
in vivo dissolution
laminar
turbulent
particle-liquid Reynolds number
Sherwood
Prandtl
eddies
dissipation
energy cascade
boundary layer separation
convective diffusion
saturation solubility
kinematic viscosity
particle size
particle morphology
surface roughness
microparticles
flow pattern
stirring
paddle
basket
fluid velocity
gastrointestinal motility
gastric emptying
caloric liquids
release kinetics
osmolality
pH
liquid-solid meal
intestinal transit
interspecies
canine intestine
human intestine
chyme volume
bulk flow
drug absorption
nutrients
omnivores
primates
carnivores
malabsorption
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Abstract:

The first two sections of the monograph present an introduction into basic hydrodynamics relevant to in vitro dissolution testing including V. G. Levichs convective diffusion theory and the authors combination model. This part is followed by hydrodynamic considerations of in vivo dissolution including hydrodynamic problems inherent to in vivo bioavailability of solid oral dosage forms. Hydrodynamics in the upper GI tract contribute to in vivo dissolution. Our ability to forecast dissolution of poorly soluble drugs in vitro depends on our knowledge of and ability to control hydrodynamics as well as other factors influencing dissolution. Provided suitable conditions (apparatus, hydrodynamics, media) are chosen for the dissolution test, it seems possible to predict dissolution limitations to the oral absorption of drugs and to reflect variations in hydrodynamic conditions in the upper GI tract. The fluid volume available for dissolution in the gut lumen, the contact time of the dissolved compound with the absorptive sites and the particle size have been identified as the main hydrodynamic determinants for the absorption of poorly soluble drugs in vivo. The influence of these factors is usually more pronounced than that of the motility pattern or the gastrointestinal flow rates per se.

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