One- and Multidimensional Liquid Chromatographic and Mass Spectrometric Strategies for the Quality Control of Natural, Synthetic and Therapeutic Peptides

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dc.contributor.advisor Lämmerhofer, Michael (Prof. Dr.)
dc.contributor.author Karongo, Ryan Icharia
dc.date.accessioned 2022-11-11T09:27:37Z
dc.date.available 2022-11-11T09:27:37Z
dc.date.issued 2022-11-11
dc.identifier.uri http://hdl.handle.net/10900/132961
dc.identifier.uri http://nbn-resolving.de/urn:nbn:de:bsz:21-dspace-1329611 de_DE
dc.identifier.uri http://dx.doi.org/10.15496/publikation-74316
dc.description.abstract The demand for therapeutic and synthetic peptides has been steadily increasing in the past decade. They occupy an interesting chemical space between traditional small molecule drugs and large ones such as proteins and are predominantly accessible through the synthetic route according to Merrifield, which is inherently prone to various peptide related impurities that pose a challenge for their quality control. The current state-of-the-art methodology is limited to RPLC (0.1 % TFA) hyphenated to UV detection, where co-eluting and chiral impurities likely remain unrevealed. Hence, sophisticated analytical strategies were developed to recognize various impurities utilizing both chemo- and enantioselective multidimensional liquid chromatographic approaches combined with high resolution mass spectrometry and various complementary detection methods. en
dc.language.iso en de_DE
dc.publisher Universität Tübingen de_DE
dc.rights ubt-podok de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=de de_DE
dc.rights.uri http://tobias-lib.uni-tuebingen.de/doku/lic_mit_pod.php?la=en en
dc.subject.ddc 500 de_DE
dc.subject.other multidimensional chromatography en
dc.subject.other mass spectrometry en
dc.subject.other therapeutic peptides en
dc.title One- and Multidimensional Liquid Chromatographic and Mass Spectrometric Strategies for the Quality Control of Natural, Synthetic and Therapeutic Peptides en
dc.type PhDThesis de_DE
dcterms.dateAccepted 2022-04-28
utue.publikation.fachbereich Pharmazie de_DE
utue.publikation.fakultaet 7 Mathematisch-Naturwissenschaftliche Fakultät de_DE
utue.publikation.noppn yes de_DE

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